BMI and other Risk Factors Effects on Colon Cancer Prognosis in Pakistan

  • Saira Saleem Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore
  • Iffat Aleem Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore
  • Muhammad Zeshan Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore
  • Muhammad Abu Bakar Department of Cancer Registry and Clinical Data Management, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
  • Aribah Atiq Department of Pathology, Shaukat Khanum Memorial Cancer hospital and Research Centre, Lahore
  • Muhammad Tahseen Department of Pathology, Shaukat Khanum Memorial Cancer hospital and Research Centre, Lahore
  • Mohammad Tariq Mahmood Department of Pathology, Shaukat Khanum Memorial Cancer hospital and Research Centre, Lahore
  • Sadia Hassan Department of Research, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore
  • Aamir Ali Syed Department of Surgical Oncology, Shaukat Khanum Memorial Cancer hospital and Research Centre, Lahore
  • Mudassar Hussain Department of Pathology, Shaukat Khanum Memorial Cancer hospital and Research Centre, Lahore
  • Asad Hayat Ahmad Department of Pathology, Shaukat Khanum Memorial Cancer hospital and Research Centre, Lahore
  • Shahid Khattak Department of Surgical Oncology, Shaukat Khanum Memorial Cancer hospital and Research Centre, Lahore
  • Muhammed Aasim Yusuf Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
Keywords: Body mass index, balanced diet, colon cancer, lifestyle choices, risk factors

Abstract

Introduction: Asian developing countries share the burden of colorectal cancer (CRC) with rising mortality rates. This prospective study aims to apprehend the clinical relevance of age, gender, lifestyle choices (dietary habits and addiction), and body mass index (BMI) to the occurrence and progression of colon cancer (CC). Methods: A cohort of non-cancer and CC patients of South-Central Asian origin registered for screening colonoscopy or surgery at Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH&RC), Lahore, Pakistan, from 2015 - 2020 was identified. BMI (Kg/m2) was classified according to the World Health Organization (WHO) criteria as underweight (<18.5 Kg/m2), normal weight (18.5-24.9 Kg/m2) and overweight (≥25 Kg/m2). Results: Among 236 participants, 99 (41.9%) belonged to the NC group, and 137 (58.1 %) participants had CC. Overall, participants included 74 women and 162 men aged 20 - 85 years (mean ± SD; 49.9 ± 14.9). Notably, 46.0 % of cancer patients had a family history of cancer. There was a direct relationship between CC with abnormal BMI (underweight and overweight), positive smoking history and positive family history of cancer. Conclusion: Being underweight or overweight is a potential risk factor for CC patients. The overall survival in patients with CC is clinically associated with lifestyle choices before CC diagnosis. A balanced diet, walking and other forms of exercise should be strongly recommended to the community and those undergoing screening colonoscopy.

Published
2022-06-30
How to Cite
1.
Saleem S, Aleem I, Muhammad Zeshan, Muhammad Abu Bakar, Atiq A, Tahseen M, Mahmood MT, Hassan S, Syed AA, Mudassar Hussain, Ahmad AH, Shahid Khattak, Muhammed Aasim Yusuf. BMI and other Risk Factors Effects on Colon Cancer Prognosis in Pakistan . J Cancer Allied Spec [Internet]. 2022Jun.30 [cited 2022Oct.7];8(2). Available from: https://journals.sfu.ca/jcas/index.php/jcas/article/view/477
Section
Original Research Article