• Nazia Rashid Shaukat Khanum Memorial Cancer Hospital & RC
  • Aamna Hassan Shaukat Khanum Memorial Cancer Hospital & RC
  • Noreen Akhter Shaukat Khanum Memorial Cancer Hospital & RC
  • Abdul Hameed Ittefaq Hospital, Lahore


A 27-year-old male underwent total thyroidectomy for thyroid swelling. Histopathology showed papillary thyroid carcinoma [T3 - 6.0 cm] with extra-thyroidal extension. The patient was treated with 150 mCi radioactive iodine
(RAI) as adjuvant ablative therapy. Radioiodine refractory disease was identified 1-year post-RAI therapy with elevated thyroglobulin levels and negative I-131 whole body scan. F-18 FDG positron emission tomography/computed
tomography scan showed activity in the right thyroid bed and multilevel right cervical nodes. Right-sided modified neck dissection was done, which showed Castleman disease (hyaline vascular type) in right cervical nodes. The most probable cause of elevated tumour markers was found out to be 0.6 cm right thyroid bed nodule on follow-up ultrasonography. Our patient also had coexistent conditions as; osteopoikilosis and Hepatitis C along with thyroid carcinoma.

Key words: Castleman disease, lymph node, radioiodine, thyroid cancer

Author Biographies

Nazia Rashid, Shaukat Khanum Memorial Cancer Hospital & RC
Nuclear Medicine, Resident Doctor
Aamna Hassan, Shaukat Khanum Memorial Cancer Hospital & RC
Consultant Nuclear Physician, Nuclear Medicine Department, SKMCH&RC
Noreen Akhter, Shaukat Khanum Memorial Cancer Hospital & RC

Consultant Pathologist,

Pathology Department, SKMCH&RC

Abdul Hameed, Ittefaq Hospital, Lahore
Consultant Hematologist/Oncologist


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How to Cite
Rashid N, Hassan A, Akhter N, Hameed A. CASTLEMAN DISEASE: A GREAT MIMICKER OF METASTASES IN RADIOIODINE REFRACTORY THYROID CANCER. J Cancer Allied Spec [Internet]. 2018Dec.31 [cited 2021Sep.17];4(4). Available from: