SENTINEL LYMPH NODE SCINTIGRAPHY IN BREAST CARCINOMA- COMPARISON OF TWO VERSUS FOUR INJECTION SITE TECHNIQUE

  • Yasir Majeed Shaukat Khanum Memorial Cancer Hospital and Research Center
  • Saima Riaz Shaukat Khanum Memorial Cancer Hospital and Research Center
  • Muhammad Zulqarnain Chaudry Shaukat Khanum Memorial Cancer Hospital and Research Center
  • Muhammad Khalid Nawaz Shaukat Khanum Memorial Cancer Hospital and Research Center

Abstract

Purpose: Sentinel lymph node (SLN) is the first regional node that drains lymph from the primary tumour and receives seeding of metastatic cells. Axillary node dissection remains the most reliable predictor of disease outcome. Controversies still exist about several aspects of lymphatic mapping and SLN biopsy for breast cancer, including number of radioisotope injection. The purpose of this study is to evaluate the success rate of different number of injection sites in the detection of SLN in breast cancer.


Materials and Methods: A total of 120 consecutive breast cancer patients were divided into two groups. Group A (60 patients) received four intradermal periareolar (ID-PA) injections. Group B (60 patients) received two ID-PA injections.Imaging was carried out at 45 min post-injection. A gamma probe was used to explore the SLNs during surgery.


Results: In Group A, 60 females with the mean age of 50.77 years were included in the study. 34 (56%) patients had single SLN. 25 (41.7%) had SLN with the second tier. 1 (1.7%) was negative. Group B included 60 patients (59 females and 1 male) with the mean age of 51.9 years. In 30 (50%) patients, single SLN was detected. 29 (48.3%) had SLN with the second tier. 1 (1.7%) was negative.

Conclusion: SLN mapping with two periareolar ID injections carries less radiation dose and less pain as compared to the four injections with equal sensitivity for the visualization of SLNs.

Key words: Breast cancer, intradermal injection, sentinel lymph node, Tc99 human serum albumin

Author Biographies

Yasir Majeed, Shaukat Khanum Memorial Cancer Hospital and Research Center

Fellow PET CT

Nuclear Medicine Department

Saima Riaz, Shaukat Khanum Memorial Cancer Hospital and Research Center

Fellow PET CT

Nuclear Medicine Department

Muhammad Zulqarnain Chaudry, Shaukat Khanum Memorial Cancer Hospital and Research Center

Consultant Surgeon

Surgical Oncology

Muhammad Khalid Nawaz, Shaukat Khanum Memorial Cancer Hospital and Research Center

Consultant Nuclear Physician

Nuclear Medicine Department

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Published
2017-04-01
How to Cite
1.
Majeed Y, Riaz S, Chaudry MZ, Nawaz MK. SENTINEL LYMPH NODE SCINTIGRAPHY IN BREAST CARCINOMA- COMPARISON OF TWO VERSUS FOUR INJECTION SITE TECHNIQUE. J Cancer Allied Spec [Internet]. 2017Apr.1 [cited 2021Jul.25];3(1). Available from: https://journals.sfu.ca/jcas/index.php/jcas/article/view/96
Section
Original Research Article