PRIMARY BILATERAL BREAST LYMPHOMA: A REVIEW OF LITERATURE AND REPORT OF FOUR CASES FROM A SINGLE CENTRE

  • Razia Bano Department of Surgical Oncology Shaukat Khanum Memorial Cancer Hospital & Research Centre Lahore
  • Amina Iqbal Khan SKMCH&RC Lahore
  • Amna Shahraf Anesthesia department CMH Rawalpindi
  • Mahwish Abid Surgery department, CMH Rawalpindi

Abstract

Primary breast lymphoma is a rare entity and carries poor prognosis, bilateral breast lymphoma is even rarer and carries worst prognosis. Bilateral breast lymphoma is a rare disease and lacks treatment. Out of the 2766 cases of non- Hodgkin’s lymphoma registered at our institute from 1994 to 2013, 31 cases of breast lymphoma were found, of which four cases had bilateral involvement. In this review, we describe clinical presentation, histopathological subtypes, treatment administered and outcome of those four cases retrospectively. All patients were female with a median age of 31 years (range 24–64 years). Three patients were diagnosed with diffuse large B-cell lymphoma and mucosa associated lymphoid tissue lymphoma detected in one patient. Chemotherapy remained the main treatment modality and surgery (excision biopsy) was reserved for diagnostic purpose only, none of the patients received radiation therapy.

Key words: Breast lymphoma, histopathological subtypes, palliation 

References

Arber DA, Simpson JF, Weiss LM, et al. Non-Hodgkin’s lymphoma involving the breast. Am J Surg Pathol 1994;18:288-95.

Jeanneret-Sozzi W, Taghian A, Epelbaum R, et al. Primary breast lymphoma: Patient pro le, outcome and prognostic factors. A multicentre rare cancer network study. BMC Cancer 2008;8:86.

Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer 1972;29:1705-12.

Brustein S, Filippa DA, Kimmel M, et al. Malignant lymphoma of the breast. A study of 53 patients. Ann Surg 1987;205:144-50.

Ganjoo K, Advani R, Mariappan MR, et al. Non-Hodgkin lymphoma of the breast. Cancer 2007;110:25-30.

Ryan G, Martinelli G, Kuper-Hommel M, et al. Primary diffuse large B-cell lymphoma of the breast: Prognostic factors and outcomes of a study by the international extranodal lymphoma study group. Ann Oncol 2008;19:233-41.

Dawn B, Perry MC. Bilateral non-Hodgkin’s lymphoma of the breast mimicking mastitis. South Med J 1997;90:328-9.

Fukuhara S, Watanabe T, Munakata W, et al. Bulky disease has an impact on outcomes in primary diffuse large B-cell lymphoma of the breast: A retrospective analysis at a single institution. Eur J Haematol 2011;87:434-40.

Julen O, Dellacasa I, Pelte MF, et al. Primary breast lymphomas. Rare Tumors 2009;1:e14.

Jeon HJ, Akagi T, Hoshida Y, et al. Primary non-hodgkin malignant lymphoma of the breast. An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan. Cancer 1992;70:2451-9.

Sabaté JM, Gómez A, Torrubia S, et al. Lymphoma of the breast: Clinical and radiologic features with pathologic correlation in 28 patients. Breast J 2002;8:294-304.

Joks M, Myśliwiec K, Lewandowski K. Primary breast lymphoma-a review of the literature and report of three cases. Arch Med Sci 2011;7:27-33.

Brogi E, Harris NL. Lymphomas of the breast: Pathology and clinical behavior. Semin Oncol 1999;26:357-64.

Gopal S, Awasthi S, Elghetany MT. Bilateral breast MALT lymphoma: A case report and review of the literature. Ann Hematol 2000;79:86-9.

Aviv A, Tadmor T, Polliack A. Primary diffuse large B-cell lymphoma of the breast: Looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol 2013;24:2236-44.

Hosein PJ, Maragulia JC, Salzberg MP, et al. A multicentre study of primary breast diffuse large B-cell lymphoma in the rituximab era. Br J Haematol 2014;165:358-63.

Validire P, Capovilla M, Asselain B, et al. Primary breast non Hodgkin’s lymphoma: A large single center study of initial characteristics, natural history, and prognostic factors. Am J Hematol 2009;84:133-9.

Jennings WC, Baker RS, Murray SS, et al. Primary breast lymphoma: The role of mastectomy and the importance of lymph node status. Ann Surg 2007;245:784-9.

Published
2016-08-31
How to Cite
1.
Bano R, Khan AI, Shahraf A, Abid M. PRIMARY BILATERAL BREAST LYMPHOMA: A REVIEW OF LITERATURE AND REPORT OF FOUR CASES FROM A SINGLE CENTRE. J Cancer Allied Spec [Internet]. 2016Aug.31 [cited 2020Aug.15];2(2). Available from: https://journals.sfu.ca/jcas/index.php/jcas/article/view/70