Dopamine-Agonist Induced Cerebrospinal Fluid Rhinorrhea; a Case Report

  • Hira Irfan Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
  • Ahmed Imran Siddiqi Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
  • Umal Azmat Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
  • Waqas Shafiq Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
  • Muhammad Atif Naveed Department of Radiology, Shaukat Khanum Memorial Cancer hospital and Research Centre, Lahore, Pakistan
  • Irfan Yousaf Department of Surgical Oncology, Shaukat Khanum Memorial Cancer hospital and Research Centre, Lahore, Pakistan
Keywords: Cerebrospinal fluid, dopamine agonist, meningitis, prolactinoma, rhinorrhea, sphenoid sinus, trans-sphenoidal surgery

Abstract

Introduction: Prolactinomas are the most common pituitary adenomas. Medical therapy with dopamine agonists (DA) is the mainstay of treatment and rarely requires surgical manipulation. Patients may rarely present with cerebrospinal fluid (CSF) rhinorrhea after starting therapy with DA in case of massive or invasive prolactinomas. Case Description: We present a case of a 29-year-old lady with invasive prolactinoma who presented with CSF rhinorrhea after a month of starting bromocriptine therapy with the development of meningitis and warranting early surgical repair. Practical Implications: Patients with macroprolactinoma should be closely monitored initially after starting on dopamine agonists to avoid life-threatening complications.

Published
2021-01-11
How to Cite
1.
Irfan H, Siddiqi AI, Azmat U, Shafiq W, Naveed MA, Yousaf I. Dopamine-Agonist Induced Cerebrospinal Fluid Rhinorrhea; a Case Report . J Cancer Allied Spec [Internet]. 2021Jan.11 [cited 2022Oct.5];7(1). Available from: https://journals.sfu.ca/jcas/index.php/jcas/article/view/389