SOLITARY FIBROUS TUMOR OF BREAST

  • Sadaf Noor Pathology department, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore
  • Noreen Akhtar Pathology department, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore
  • Usman Hassan Pathology department, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore
  • Marium Hameed Pathology department, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore

Abstract

Solitary fibrous tumours (SFTs) are fibroblastic mesenchymal tumour primarily identified in the pleura but are now being reported in other anatomic sites as well. SFT is generally characterised as a radiologically confined neoplasm composed of a proliferated spindle cells arranged in patternless manner. Intervening tissue shows prominent haemangiopericytoma-like vessels. Stroma is usually fibrous. Tumour is positive for CD34. SFT has a specific translocation representing fusion NAB2 with STAT6 genes. This translocation can be highlighted with very good specificity and sensitivity using STAT6 immunohistochemical stain. Some cases of SFTs have also been described in the breast. Rarely, SFT can show aggressive behaviour. SFT enters the differential diagnoses of benign and malignant spindle cell tumours of breast and it is, therefore, important that its clinical, radiological and pathological features are known to clinicians and diagnosticians.

Key words: CD34, myofibroblastoma, NAB2-STAT6, solitary fibrous tumour

Author Biography

Sadaf Noor, Pathology department, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore
Fellow Surgical pathology

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Published
2019-06-30
How to Cite
1.
Noor S, Akhtar N, Hassan U, Hameed M. SOLITARY FIBROUS TUMOR OF BREAST. J Cancer Allied Spec [Internet]. 2019Jun.30 [cited 2022Aug.16];5(2). Available from: https://journals.sfu.ca/jcas/index.php/jcas/article/view/231