A Wise-Compassionate Framework (WCF) was designed to offer educational leaders a recognizable and comprehensive approach that captures critical race theory as a guide to the academic, social-emotional, health, cultural, and behavioral needs of all students. The WCF complements and builds upon Multi-Tiered Systems of Support (MTSS) and the Whole School, Whole Community (WSCC) model by infusing compassionate research and social-psychological approaches called wise interventions. The design of the WCF was developed during the onset of the COVID-19 pandemic. The WCF is an educational model that seeks to increase systemic compassion through wise interventions and best practices, both in person and in online settings. Trauma-informed practices, social justice responsibility, and evidence-based research are embodied throughout the tiers of the WCF. This article provides an overview of how the WCF can be utilized in an educational environment. A compassionate approach anchored in evidence-based research can support schools to heal through the COVID-19 pandemic and realize the racial tension amplified by the murder of George Floyd by the police.