Polymorphic Ventricular Tachycardia ( PMVT ) secondary to a combination of Azithromycin and Fluoxetine in a case of Acute Pancreatitis

Abstract

We report on a 51 year old male was admitted to hospital with acute pancreatitis related excessive alcohol consumption. He was on Fluoxetine 20 mg  QD for depression. He needed treatment with Azithromycin for respiratory infection.  Two days later, he had an episode of polymorphic Ventricular tachycardia secondary to excessive QT from which he was successively resuscitated. At the time of the cardiac arrest, he had normal serum electrolyte levels. He was also sent for a cardiac catheterization that revealed normal Left ventricular systolic function and normal coronaries. Over the course of several days after this event, his QTc interval eventually normalized. Review of the available literature, suggests that the polymorphic ventricular tachycardia (PMVT) in this case could be a result of some of the medications he was on around the time of the event. The most likely culprits here are Azithromycin and Fluoxetine.