The Monod-Wyman-Changeux model is described and reviewed. In particular, the chapter scrutinizes the use of the so-called state-of-function R derived from the MWC theory and suggests another function-of-state for use on systems without spontaneous activity. The chapter ends with a recommendation to use genuine two-state models such as the allosteric two-state model (ATSM) and the homotropic two-state model (HOTSM) for dose-response data obtained at equilibrium. For future analysis of synagic data the reader is encouraged to develop and implement the hybrid model combined of these two models, that is, the so called four-pane two-state model (FP-TSM), to its full potential.

Citation: Bindslev N 2008. DOI: 10.3402/bindslev.2008.20