CD4+ AND CD8+ T-CELLS EXPRESSING INTERFERON GAMMA IN ACTIVE PULMONARY TUBERCULOSIS PATIENTS

Authors

  • Betty Agustina Tambunan Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia;
  • Hery Priyanto Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia;
  • Jusak Nugraha Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia;
  • Soedarsono Soedarsono Department of Pulmonology and Respiration Medicine, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia

DOI:

https://doi.org/10.21010/Ajid.v12i1S.6

Keywords:

IFN-γ, CD4 , CD8 , new active pulmonary tuberculosis, Flow cytometry, OAT

Abstract

Background: Tuberculosis (TB) is a global health problem. Immune response through CD4+ and CD8+ T cells is needed to produce Interferon gamma (IFN-γ), a cytokine eliminate Mycobacterium tuberculosis. We aimed to compare the cellular immune response based on the percentage of CD4+ and CD8+ T cells expressing interferon gamma in active pulmonary tuberculosis patients before and after 2 months of tuberculosis treatment. Methods: It is a longitudinal cohort study included 12 patients with new active pulmonary TB of the Pulmonary Hospital, Surabaya. The CD4+ and CD8+ T cells expressing interferon gamma was measured by flow cytometry method. Results: The mean CD4+ interferon gamma percentage of new active pulmonary TB before treatment was higher than 2 months after tuberculosis treatment (4.48% vs. 1.52%) and there was a significantly decreased (p = 0.025). The mean CD8+ interferon gamma percentage of new active pulmonary TB before treatment was higher than 2 months after tuberculosis treatment (3.56% vs. 2.89%) but not significantly decreased (p = 0.186). Conclusions: The mean CD4+ IFN-γ percentage of new active pulmonary TB before treatment was higher than 2 months after treatment, suggesting that CD4+ T cells expressing IFN-γ play a role in protection against pulmonary TB infectio

Author Biographies

Betty Agustina Tambunan, Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia;

Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia;

Hery Priyanto, Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia;

Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia;

Jusak Nugraha, Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia;

Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia;

Soedarsono Soedarsono, Department of Pulmonology and Respiration Medicine, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia

Department of Pulmonology and Respiration Medicine, Faculty of Medicine, Universitas Airlangga-Soetomo Hospital, Surabaya, Indonesia

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Published

2018-03-07

How to Cite

Tambunan, B. A., Priyanto, H., Nugraha, J., & Soedarsono, S. (2018). CD4+ AND CD8+ T-CELLS EXPRESSING INTERFERON GAMMA IN ACTIVE PULMONARY TUBERCULOSIS PATIENTS. African Journal of Infectious Diseases (AJID), 12(1S), 49–53. https://doi.org/10.21010/Ajid.v12i1S.6

Issue

Vol. 12 No. 1S (2018): Special Issue

Section

Articles

License

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