EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING GRAM NEGATIVE BACTERIA IN IRAN

Authors

  • Hamed Ebrahimzadeh Leylabadlo
  • Tala Pourlak
  • Abed Zahedi bialvaei
  • Mohammad Aghazadeh
  • Mohammad Asgharzadeh
  • Hossein Samadi Kafil

DOI:

https://doi.org/10.21010/ajid.v11i2.6

Keywords:

extended-spectrum β-lactamase, antibiotic resistance, Acinetobacter baumannii, Pseudomonas aeruginosa, Iran.

Abstract

Background: The emergence and spread of extended spectrum β-lactamase (ESBL)-producing Gram- negative bacteria (GNB), particularly in Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa, have increased all over the world. ESBLs are characterized by their ability to hydrolyze β-lactams, early cephalosporins, oxyimino-thiazolyl cephalosporins, and monobactams, but not cephamycins or carbapenems. The rate of nosocomial infections caused by ESBL-producing GNB in Asia Pacific has increased and several studies have identified their prevalence in the region. The aim of this study is to review the prevalence of ESBL-producing GNB in the West Asia and the Middle East with a particular focus on Iran. Materials and Methods: The available evidence from various studies (Microbia and clinical studies, retrieved from the PubMed, and Scopus databases) regarding the ESBL producing Gram negative bacteria in Iran were evaluated. Results: In almost all parts of the country, high resistance has been observed, especially in the central part of Iran. Up to 89.8% Escherichia coli, 72.1% Klebsiella pneumonia, 84.2% Acinetobacter baumannii, and 83.8% Pseudomonas aeruginosa isolates are ESBL positive. Conclusion: The present study showed the increasing prevalence of ESBLs in different regions of Iran, which could be useful to strategic policy towards reducing reduce their prevalence.

Author Biography

Hamed Ebrahimzadeh Leylabadlo

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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Published

2017-06-08

How to Cite

Leylabadlo, H. E., Pourlak, T., bialvaei, A. Z., Aghazadeh, M., Asgharzadeh, M., & Kafil, H. S. (2017). EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING GRAM NEGATIVE BACTERIA IN IRAN. African Journal of Infectious Diseases (AJID), 11(2), 39–53. https://doi.org/10.21010/ajid.v11i2.6

Issue

Vol. 11 No. 2 (2017)

Section

Review

License

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